Effects of a lipid-encapsulated zinc oxide supplement on growth performance and intestinal morphology and digestive enzyme activities in weanling pigs

Jang, Insurk; Kwon, Chang Hoon; Ha, Duck Min; Jung, Dae Yun; Kang, Sun Young; Park, Man Jong; Han, Jeong Hee; Park, Byung-Chul; Lee, Chul Young

doi:10.1186/2055-0391-56-29

Journal of Animal Science and Technology

Table 3 Effects of dietary supplementations of native ZnO and lipid-encapsulated ZnO (LE ZnO) on hepatic and circulating Zn concentrations, intestinal villus structure, and specific activities of digestive enzymes in weanling pigs

From: Effects of a lipid-encapsulated zinc oxide supplement on growth performance and intestinal morphology and digestive enzyme activities in weanling pigs

Enzyme				Dietary supplementation (ppm as Zn)								Contrast P-value
	Native ZnO¹⁾			LE ZnO							P-value	LE ZnO vs.		Within LE ZnO
	100	2,500	SEM	8% lipid²⁾		10% lipid²⁾		12% lipid²⁾		SEM		Native ZnO		10% lipid vs.		100 vs.
				100	250	100	250	100	250			100	2,500	8%	12%	250
Zn concentration
Liver (μg/g)	34.9	412.1	13.6	33.3	55.4	27.8	33.5	36.3	39.0	19.2	<0.01	0.87	<0.01	0.48	0.72	0.52
Serum (μg/ml)	1.78	2.45	0.14	1.53	1.63	1.52	1.50	1.14	1.62	0.22	<0.01	0.10	<0.01	0.75	0.57	0.31
Villus structure
Duodenum
VH (μm)	292	284	14	299	365	299	315	277	323	20	0.07	0.21	0.10	0.22	0.71	<0.01
CD(μm)	230	227	11	240	282	238	276	231	256	16	0.07	0.07	0.05	0.78	0.41	<0.01
VH:CD	1.27	1.26	0.04	1.25	1.29	1.26	1.15	1.20	1.26	0.05	0.56	0.37	0.66	0.21	0.60	0.98
Jejunum
VH (μm)	280	252	16	254	315	240	266	275	263	21	0.31	0.54	0.38	0.15	0.46	0.17
CD(μm)	230	206	15	234	262	225	238	251	218	20	0.49	0.64	0.08	0.44	0.89	0.87
VH:CD	1.21	1.16	0.03	1.09	1.20	1.07	1.12	1.11	1.20	0.04	0.03	0.02	0.30	0.21	0.13	<0.01
Ileum
VH (μm)	245	209	13	215	247	245	234	230	232	19	0.56	0.48	0.11	0.67	0.67	0.62
CD(μm)	228	186	13	205	221	238	224	238	180	19	0.15	0.73	0.05	0.33	0.24	0.24
VH:CD	1.10	1.21	0.07	1.30	1.16	1.03	1.05	1.09	1.31	0.11	0.36	0.54	0.50	0.08	0.15	0.71
Enzyme activity (μmol end product · mg protein^-1 · min^-1)
Sucrase
Duodenum	0.043	0.034	0.008	0.076	0.039	0.040	0.049	0.041	0.044	0.012	0.25	0.61	0.14	0.26	0.89	0.39
Jejunum	0.874	0.537	0.225	0.319	0.401	0.160	0.628	0.509	0.170	0.318	0.59	0.06	0.51	0.91	0.86	0.79
Ileum	0.098	0.117	0.032	0.105	0.099	0.088	0.107	0.094	0.119	0.046	1.00	0.91	0.68	0.93	0.86	0.74
Maltase
Duodenum	5.18	4.41	1.10	8.15	4.56	5.98	7.71	5.34	7.80	1.56	0.36	0.28	0.10	0.76	0.86	0.88
Jejunum	15.87	12.70	3.48	8.35	12.95	10.28	14.10	13.88	5.38	4.92	0.76	0.22	0.64	0.76	0.61	0.99
Ileum	4.20	5.39	1.49	5.11	4.02	2.91	6.27	4.13	3.95	2.11	0.96	0.91	0.57	0.99	0.80	0.69
LAP
Duodenum	2.00	2.30	0.36	2.19	1.91	1.99	2.72	1.90	3.20	0.50	0.53	0.45	0.96	0.55	0.70	0.17
Jejunum	3.15	2.73	0.27	2.37	2.53	3.17	2.51	3.25	2.20	0.38	0.30	0.14	0.86	0.31	0.77	0.11
Ileum	1.76	1.93	0.29	2.04	1.71	1.68	1.94	1.61	1.81	0.41	0.99	0.90	0.69	0.88	0.81	0.89
Amylase (PAN)	241.2	142.1	23.0	262.1	185.1	224.3	240.7	237.6	231.4	31.4	0.06	0.67	<0.01	0.78	0.95	0.39
Trypsin (PAN)	0.156	0.107	0.022	0.149	0.127	0.150	0.184	0.160	0.197	0.032	0.43	0.86	0.06	0.37	0.71	0.53

¹⁾Data are means of 8 animals in each group.
²⁾Denotes the percentage of lipid (w/w) encapsulating the ZnO particle. Data are means of 4 animals in each group.
VH, villus height; CD, crypt depth; LAP, leucine aminopeptidase; PAN, pancreas.

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ISSN: 2055-0391

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