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Table 4 Effects of dietary supplementations of 100 ppm of ZnO without (BASAL) or with 120 ppm of apramycin (ANTIBIO), 2,500 ppm of ZnO (HIGH), and 100 ppm of the lipid-encapsulated ZnO (LE) on histological measurements of the intestine in weanling pigs challenged with 5 × 10 8cfu of ETEC K88

From: Effects of a lipid-encapsulated zinc oxide dietary supplement, on growth parameters and intestinal morphology in weanling pigs artificially infected with enterotoxigenic Escherichia coli

Item BASAL ANTIBIO HIGH LE SEM P- value
Goblet cell density, cells/mm2
Duodenum       
Villus 143b 145b 230a 211a 13.2 <0.01
Crypt 215b 221b 377a 356a 24.3 <0.01
Jejunum       
Villus 102d 134c 164b 192a 9.1 <0.01
Crypt 241c 260c 305b 349a 11.1 <0.01
Ileum       
Villus 187 196 192 183 18.7 0.97
Crypt 409 403 439 428 15.0 0.32
Colon       
Mucosa 475b 515b 624a 675a 32.8 <0.01
Mucosal morphology
Duodenum       
VH1, μm 367 386 424 435 19 0.07
CD2, μm 254 252 262 256 11 0.93
VH:CD 1.45 1.53 1.62 1.72 0.08 0.10
Jejunum       
VH, μm 331 340 305 336 17 0.52
CD, μm 257a 255a 200b 205b 17 0.04
VH:CD 1.31 1.41 1.52 1.64 0.10 0.12
Ileum       
VH, μm 297 300 295 305 9 0.89
CD, μm 250 239 229 224 7 0.06
VH:CD 1.19a 1.26a 1.29ab 1.36b 0.03 0.02
  1. 1VH = villus height.
  2. 2CD = crypt depth.
  3. a-dMeans with no common superscript within a row differ (P < 0.05).