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Table 3 Effects of oral administration of the MYCI mixture on fecal PEDV shedding of newborn piglets after an oral administration of the virusa)

From: Medicinal herb extracts ameliorate impaired growth performance and intestinal lesion of newborn piglets challenged with the virulent porcine epidemic diarrhea virus

Time Not challenged Challenged (Chal) p-value
Control (n = 5) MYCI (n = 5) Control (n = 6) MYCI (n = 6) Chal MYCI
0 h 0/5 0/5 0/6 0/6 N/Ab N/A
12 h 0/5 0/5 0/6 0/6 N/A N/A
1 d 0/5 0/5 2/6 2/6 0.044 1.000
2 d 0/5 0/5 6/6 6/6 <0.001 1.000
3d 0/5 0/5 6/6 5/6 <0.001 0.670
4 d 0/5 0/5 4/6 2/6 0.009 0.338
5 d 0/5 0/5 4/6 3/6 0.003 0.647
6 d 0/5 0/5 3/5c 3/6 0.006 0.890
7 d 0/5 0/5 2/5 2/6 0.034 0.916
Total 0/45 0/45 27/52 23/54 <0.001 0.460
  1. aNewborn piglets received an oral challenge with 3 × 103.5 TCID50 of PEDV in PBS or PBS only and daily administration 60 mg of the MYCI mixture suspended in milk replacer or the vehicle for 7 days. Presence of the PEDV in feces was determined by reverse transcription-polymerase chain reaction. Data represent the number of PEDV-positive animals per total animals
  2. bN/A, Not applicable
  3. cOne animal died