Medicinal herb extracts ameliorate impaired growth performance and intestinal lesion of newborn piglets challenged with the virulent porcine epidemic diarrhea virus

Table 3 Effects of oral administration of the MYCI mixture on fecal PEDV shedding of newborn piglets after an oral administration of the virus^a)

Time	Not challenged		Challenged (Chal)		p-value
Time	Control (n = 5)	MYCI (n = 5)	Control (n = 6)	MYCI (n = 6)	Chal	MYCI
0 h	0/5	0/5	0/6	0/6	N/A^b	N/A
12 h	0/5	0/5	0/6	0/6	N/A	N/A
1 d	0/5	0/5	2/6	2/6	0.044	1.000
2 d	0/5	0/5	6/6	6/6	<0.001	1.000
3d	0/5	0/5	6/6	5/6	<0.001	0.670
4 d	0/5	0/5	4/6	2/6	0.009	0.338
5 d	0/5	0/5	4/6	3/6	0.003	0.647
6 d	0/5	0/5	3/5^c	3/6	0.006	0.890
7 d	0/5	0/5	2/5	2/6	0.034	0.916
Total	0/45	0/45	27/52	23/54	<0.001	0.460

^aNewborn piglets received an oral challenge with 3 × 10^3.5 TCID₅₀ of PEDV in PBS or PBS only and daily administration 60 mg of the MYCI mixture suspended in milk replacer or the vehicle for 7 days. Presence of the PEDV in feces was determined by reverse transcription-polymerase chain reaction. Data represent the number of PEDV-positive animals per total animals
^bN/A, Not applicable
^cOne animal died

ISSN: 2055-0391