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Table 4 Effects of oral administration of the MYCI mixture on intestinal mucosal morphology of newborn piglets after an oral administration of PEDVa)

From: Medicinal herb extracts ameliorate impaired growth performance and intestinal lesion of newborn piglets challenged with the virulent porcine epidemic diarrhea virus

  Not challenged Challenged (Chal) P-value
CONb) (n = 5) MYCI (n = 5) SEM CON (n = 6) MYCI (n = 6) SEM Chal MYCI C × M
Duodenum          
VHb), μm 443 482 38.3 409 471 31.7 0.050 <0.001 0.023
CDb), μm 171 171 10.7 183 173 16.1 0.183 0.255 0.533
VH:CD 2.65 2.72 0.163 2.31 2.74 0.149 0.590 0.392 0.002
Jejunum          
VH, μm 144 151 11.7 129 154 13.3 0.156 0.002 0.030
CD, μm 157 137 13.0 170 138 9.5 0.040 <0.001 0.001
VH:CD 0.98 1.18 0.166 0.89 1.23 0.155 0.946 0.377 0.013
Ilium          
VH, μm 166 182 13.3 161 184 10.1 0.648 <0.001 0.015
CD, μm 165 166 15.9 160 142 11.0 0.001 0.027 0.048
VH:CD 1.12 1.16 0.156 1.01 1.32 0.170 0.933 0.547 0.058
  1. aNewborn piglets received an oral challenge with 3 × 103.5 TCID50 of PEDV in PBS or PBS only and daily administration 60 mg of the MYCI mixture suspended in milk replacer or the vehicle for 7 days
  2. bCON, control; VH, villus height; CD, crypt depth