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Table 1 Data of DMI, milk production, milk composition and metabolites, cytokines, and APP in the serum of dairy cows with (n = 6) and without subclinical mastitis (SCM) during the periparturient period

From: Innate immunity and carbohydrate metabolism alterations precede occurrence of subclinical mastitis in transition dairy cows

  Groupa   Effect,b P-value
Item SCM CON SEM Hs Wk Hs × Wk
DMIc (kg/d) 16.90 18.64 0.72 0.02 <0.01 0.09
Milk productiond (kg/d) 33.76 42.16 2.52 0.04 <0.01 0.37
Milk compositione (g/kg, unless otherwise stated)     
Fat 3.67 3.84 0.23 0.63 0.24 0.23
Protein 2.92 2.86 0.05 0.39 0.04 0.19
Fat:protein ratio 1.27 1.37 0.10 0.51 0.24 0.23
Lactose 4.59 4.56 0.05 0.72 0.03 0.86
SCC (103 cells/mL) 628.44 29.38 124.45 <0.01 0.20 0.21
Milk urea N (mg/dL) 17.43 15.61 1.02 0.24 0.53 0.38
TS 12.21 12.21 0.20 0.98 0.40 0.44
Serum parametersf       
Lactate (μmol/L) 3,043.38 2,242.94 149.29 <0.01 0.04 0.08
NEFA (mmol/L) 205.46 397.17 64.62 0.07 <0.01 0.14
BHBA (μmol/L) 520.81 596.03 73.09 0.50 <0.01 0.65
IL-1 (pg/mL) 299.19 296.62 4.72 0.71 <0.01 0.04
IL-6 (pg/mL) 19.05 26.70 6.42 0.47 0.15 0.10
TNF (ng/mL) 0.52 0.19 0.04 <0.01 <0.01 <0.01
Haptoglobin (mg/mL) 0.14 0.15 0.01 0.37 <0.01 <0.01
SAA (ug/mL) 23,915 8,514.32 2,517.79 <0.01 0.16 0.40
  1. aCON = cows without subclinical mastitis (health control); SCM = cows with subclinical mastitis
  2. bEffect of health status (Hs), sampling week (Wk), and health status by sampling week interaction (Hs × Wk)
  3. cDry matter intake was calculated from week -8 to +8 relative to parturition
  4. dMilk production was calculated from week +1 to +8 relative to parturition
  5. eMilk compositions were determined on week +2, +3, +5, +7 relative to parturition
  6. fSerum parameters were calculated from week -8, -4, disease, and +4 relative to parturition