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Table 1 Data of DMI, milk production, milk composition and metabolites, cytokines, and APP in the serum of dairy cows with (n = 6) and without subclinical mastitis (SCM) during the periparturient period

From: Innate immunity and carbohydrate metabolism alterations precede occurrence of subclinical mastitis in transition dairy cows

 

Groupa

 

Effect,b P-value

Item

SCM

CON

SEM

Hs

Wk

Hs × Wk

DMIc (kg/d)

16.90

18.64

0.72

0.02

<0.01

0.09

Milk productiond (kg/d)

33.76

42.16

2.52

0.04

<0.01

0.37

Milk compositione (g/kg, unless otherwise stated)

    

Fat

3.67

3.84

0.23

0.63

0.24

0.23

Protein

2.92

2.86

0.05

0.39

0.04

0.19

Fat:protein ratio

1.27

1.37

0.10

0.51

0.24

0.23

Lactose

4.59

4.56

0.05

0.72

0.03

0.86

SCC (103 cells/mL)

628.44

29.38

124.45

<0.01

0.20

0.21

Milk urea N (mg/dL)

17.43

15.61

1.02

0.24

0.53

0.38

TS

12.21

12.21

0.20

0.98

0.40

0.44

Serum parametersf

      

Lactate (μmol/L)

3,043.38

2,242.94

149.29

<0.01

0.04

0.08

NEFA (mmol/L)

205.46

397.17

64.62

0.07

<0.01

0.14

BHBA (μmol/L)

520.81

596.03

73.09

0.50

<0.01

0.65

IL-1 (pg/mL)

299.19

296.62

4.72

0.71

<0.01

0.04

IL-6 (pg/mL)

19.05

26.70

6.42

0.47

0.15

0.10

TNF (ng/mL)

0.52

0.19

0.04

<0.01

<0.01

<0.01

Haptoglobin (mg/mL)

0.14

0.15

0.01

0.37

<0.01

<0.01

SAA (ug/mL)

23,915

8,514.32

2,517.79

<0.01

0.16

0.40

  1. aCON = cows without subclinical mastitis (health control); SCM = cows with subclinical mastitis
  2. bEffect of health status (Hs), sampling week (Wk), and health status by sampling week interaction (Hs × Wk)
  3. cDry matter intake was calculated from week -8 to +8 relative to parturition
  4. dMilk production was calculated from week +1 to +8 relative to parturition
  5. eMilk compositions were determined on week +2, +3, +5, +7 relative to parturition
  6. fSerum parameters were calculated from week -8, -4, disease, and +4 relative to parturition