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Table 2 Data of DMI, milk production, milk composition, and various serum variables related to carbohydrate metabolism as well as to proinflammatory cytokines and acute phase proteins at the diagnosis week, and prior to the diagnosis of subclinical mastitis (SCM) at -8 and -4 weeks prior to expected day of parturition

From: Innate immunity and carbohydrate metabolism alterations precede occurrence of subclinical mastitis in transition dairy cows

 

-8 weeks before parturation

4 weeks before parturation

SCM diagnosis weeka

4 weeks after parturition

Item

CON

SCM

P-value

CON

SCM

P-value

CON

SCM

P-value

CON P-value

SCM

P-value

DMI (kg/d)

16.27 ± 1.04

14.94 ± 1.04

0.42

15.93 ± 0.10

12.98 ± 0.75

0.05

20.34 ± 0.56

16.23 ± 0.44

<0.01

21.16 ± 0.68

22.46 ± 1.79

0.23

Milk production (kg/d)

      

43.01 ± 1.62

28.23 ± 3.95

<0.01

42.04 ± 2.21

35.36 ± 3.96

0.17

Milk composition (g/kg, unless otherwise stated)

          

Fat

      

5.08 ± 0.45

3.32 ± 0.41

0.02

   

Protein

      

3.00 ± 0.10

2.97 ± 0.09

0.86

   

Fat : Protein ratio

      

1.69 ± 0.12

1.11 ± 0.12

<0.01

   

Lactose

      

4.54 ± 0.05

4.53 ± 0.06

0.92

   

SCC (103 cells/mL)

      

28.33 ± 5.63

1,867 ± 699

0.02

   

Milk urea N (mg/dL)

      

15.39 ± 0.76

18.70 ± 1.11

0.03

   

TS

      

12.21 ± 0.31

12.19 ± 0.26

0.95

   

Serum parameters

            

Lactate (μmol/L)

2,455 ± 349

3,478 ± 153

0.03

2,162 ± 184

3,467 ± 546

0.04

2,228 ± 320

2,215 ± 203

0.98

2,100 ± 129

2,999 ± 76

<0.01

NEFA (mmol/L)

141 ± 32.77

179 ± 42.91

0.51

194 ± 47.17

92.97 ± 10.42

0.09

756 ± 232

303 ± 55

0.11

500.43 ± 151.71

243.89 ± 39.28

0.16

BHBA (μmol/L)

352 ± 37.71

336 ± 42.62

0.78

312 ± 18.50

354 ± 3.32

0.08

827 ± 151

598 ± 176

0.35

896.73 ± 188.3

777.8 ± 91.43

0.58

IL-1 (pg/mL)

316.79 ± 6.04

308 ± 13.76

0.55

321 ± 1.59

306. ± 1.46

<0.01

277. ± 5.42

297 ± 4.50

0.02

270.57 ± 2.87

283.02 ± 7.22

0.14

IL-6 (pg/mL)

19.23 ± 5.67

13.23 ± 3.15

0.42

48.24 ± 17.51

14.75 ± 6.13

0.24

23.17 ± 5.18

23.43 ± 4.89

0.97

15.71 ± 3.27

21.73 ± 6.02

0.38

TNF (ng/mL)

0.34 ± 0.03

0.35 ± 0.02

0.96

0.27 ± 0.05

1.29 ± 0.05

<0.01

0.06 ± 0.03

0.23 ± 0.01

0.01

0.07 ± 0.04

0.28 ± 0.04

0.01

Haptoglobin (mg/mL)

0.19 ± 0.03

0.05 ± 0.01

<0.01

0.15 ± 0.01

0.07 ± 0.01

<0.01

0.12 ± 0.01

0.33 ± 0.02

<0.01

0.16 ± 0.01

0.10 ± 0.02

0.04

SAA (ug/mL)

8,448 ± 3,373

8,799 ± 1,464

0.96

3,461 ± 342

21,052 ± 12,162

0.39

10,401 ± 1722

33,705 ± 9,459

0.05

11,797 ± 1,853

31,419 ± 8,039

0.05

  1. aCows were diagnosed with subclinical mastitis (n = 6) ranging from week +2 to +3. CON = cows without subclinical mastitis (health control); SCM = cows with subclinical mastitis
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Journal of Animal Science and Technology

ISSN: 2055-0391