Table 1 Statistics for thirteen subnetworks identified by MCODE method in PPI network from complete DEGs (cutoff P < 0.05 in corrected tests of Benjamini-Hochberg)
Module | Score | Nodes | Interactions | Gene/Protein ID |
|---|---|---|---|---|
1 | 8.941 | 18 | 76 | GNAI2, BTK, RGS14, LYN, ADORA3, PDGFRA, CXCL16, NEDD9, ADCY6, RGS19, HTR5A, ADCY7, CCR2, APP, ANXA1, CNR1, PTPRC, PTPN6 |
2 | 6.087 | 24 | 70 | CD86, FNBP1, TGFB1I1, VAV1, DOK2, RAC1, CAPN3, HCK, KCNMA1, CENPE, ARRB1, BUB1B, CAPN1, ITPR2, PIK3R5, ITPR3, SYK, BMP2, DLG2, ARHGDIB, CDK6, TOP2A, SH3KBP1, FYN |
3 | 5.6 | 6 | 14 | CD74, HLA-DRA, HLA-DRB3, HLA-DMA, HLA-DQA1, HLA-DOB |
4 | 4.231 | 27 | 55 | SERPINF1, NCF2, CYBA, CORO1A, LCP1, PPP3CC, TGFB1, CFL1, PFN1, CDH2, MMP2, INSR, COL6A1, TSPO, TPM2, COL8A1, MAP2K1, CORO1B, DOK1, ICAM1, NFATC1, COL1A1, FOS, KLF4, TAGLN, MYO1F, INPP5D |
5 | 4 | 4 | 6 | CFD, CLU, GAS6, SERPINA1 |
6 | 3.879 | 34 | 64 | NTN1, CDK5RAP2, ARHGAP4, CKAP5, ICAM3, CDH1, NFKB1, IL1B, ZYX, ANAPC5, ITGAV, COL4A4, MYL12A, SPI1, ITGB7, FBN1, CNN2, MYO18B, FGR, PGR, TLR2, MKI67, ARHGAP30, PSMA6, PSMB8, RHOBTB1, COL1A2, THBS2, RHOJ, KIF14, HMHA1, TPM4, PSMD8, CEP72 |
7 | 3.6 | 6 | 9 | TUBB6, LRRK1, ACTB, RAB7A, RAB10, WIPF1 |
8 | 3.333 | 4 | 5 | PPAP2C, PLD4, PLD3, AGPAT2 |
9 | 3 | 3 | 3 | SERPINB8, SNX10, DENND2D |
10 | 3 | 3 | 3 | PRKAA2, PRKAR2B, PRKAG2 |
11 | 3 | 3 | 3 | NPNT, TINAGL1, PLIN2 |
12 | 2.8 | 16 | 21 | ACTA2, SMAD9, ARPC2, ENG, CDK1, TIMP1, MAPK15, BUB1, ACVR2B, XPO1, NCKIPSD, ACTN1, INSRR, WAS, CDC45, BMP4 |
13 | 2.667 | 4 | 4 | BCL2L14, BCL2A1, CASP3, PAX8 |