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Table 1 Statistics for thirteen subnetworks identified by MCODE method in PPI network from complete DEGs (cutoff P < 0.05 in corrected tests of Benjamini-Hochberg)

From: Analysis of protein-protein interaction network based on transcriptome profiling of ovine granulosa cells identifies candidate genes in cyclic recruitment of ovarian follicles

Module Score Nodes Interactions Gene/Protein ID
1 8.941 18 76 GNAI2, BTK, RGS14, LYN, ADORA3, PDGFRA, CXCL16, NEDD9, ADCY6, RGS19, HTR5A, ADCY7, CCR2, APP, ANXA1, CNR1, PTPRC, PTPN6
2 6.087 24 70 CD86, FNBP1, TGFB1I1, VAV1, DOK2, RAC1, CAPN3, HCK, KCNMA1, CENPE, ARRB1, BUB1B, CAPN1, ITPR2, PIK3R5, ITPR3, SYK, BMP2, DLG2, ARHGDIB, CDK6, TOP2A, SH3KBP1, FYN
3 5.6 6 14 CD74, HLA-DRA, HLA-DRB3, HLA-DMA, HLA-DQA1, HLA-DOB
4 4.231 27 55 SERPINF1, NCF2, CYBA, CORO1A, LCP1, PPP3CC, TGFB1, CFL1, PFN1, CDH2, MMP2, INSR, COL6A1, TSPO, TPM2, COL8A1, MAP2K1, CORO1B, DOK1, ICAM1, NFATC1, COL1A1, FOS, KLF4, TAGLN, MYO1F, INPP5D
5 4 4 6 CFD, CLU, GAS6, SERPINA1
6 3.879 34 64 NTN1, CDK5RAP2, ARHGAP4, CKAP5, ICAM3, CDH1, NFKB1, IL1B, ZYX, ANAPC5, ITGAV, COL4A4, MYL12A, SPI1, ITGB7, FBN1, CNN2, MYO18B, FGR, PGR, TLR2, MKI67, ARHGAP30, PSMA6, PSMB8, RHOBTB1, COL1A2, THBS2, RHOJ, KIF14, HMHA1, TPM4, PSMD8, CEP72
7 3.6 6 9 TUBB6, LRRK1, ACTB, RAB7A, RAB10, WIPF1
8 3.333 4 5 PPAP2C, PLD4, PLD3, AGPAT2
9 3 3 3 SERPINB8, SNX10, DENND2D
10 3 3 3 PRKAA2, PRKAR2B, PRKAG2
11 3 3 3 NPNT, TINAGL1, PLIN2
12 2.8 16 21 ACTA2, SMAD9, ARPC2, ENG, CDK1, TIMP1, MAPK15, BUB1, ACVR2B, XPO1, NCKIPSD, ACTN1, INSRR, WAS, CDC45, BMP4
13 2.667 4 4 BCL2L14, BCL2A1, CASP3, PAX8
  1. Abbreviations: PPI Protein–protein interaction, DEGs Differentially expressed genes