Table 2 Highly significant terms (P < 0.05 in corrected test of Benjamini-Hochberg) in BP enrichment of modules from total PPI network
Category | GO ID | GO Term | Associated Genes/proteins Found | Adjusted P-value |
|---|---|---|---|---|
Module 1 | ||||
BP | GO:0050855 | regulation of B cell receptor signaling pathway | LYN, PTPN6, PTPRC | 3.44E-06 |
BP | GO:0050866 | negative regulation of cell activation | CCR2, CNR1, LYN, PDGFRA, PTPN6 | 4.23E-06 |
BP | GO:0002703 | regulation of leukocyte mediated immunity | BTK, CCR2, LYN, PTPN6, PTPRC | 4.36E-06 |
BP | GO:0050853 | B cell receptor signaling pathway | BTK, LYN, PTPN6, PTPRC | 7.04E-06 |
BP | GO:0045577 | regulation of B cell differentiation | BTK, PTPN6, PTPRC | 1.56E-05 |
Module 2 | ||||
BP | GO:0002431 | Fc receptor mediated stimulatory signaling pathway | FYN, HCK, ITPR2, ITPR3, RAC1, SYK, VAV1 | 6.58E-08 |
BP | GO:0038094 | Fc-gamma receptor signaling pathway | FYN, HCK, ITPR2, ITPR3, RAC1, SYK, VAV1 | 8.67E-08 |
BP | GO:0002433 | immune response-regulating cell surface receptor signaling pathway involved in phagocytosis | FYN, HCK, ITPR2, ITPR3, RAC1, SYK, VAV1 | 1.68E-07 |
BP | GO:0038096 | Fc-gamma receptor signaling pathway involved in phagocytosis | FYN, HCK, ITPR2, ITPR3, RAC1, SYK, VAV1 | 1.68E-07 |
BP | GO:0048010 | vascular endothelial growth factor receptor signaling pathway | FYN, ITPR2, ITPR3, RAC1, VAV1 | 4.86E-06 |
Module 4 | ||||
BP | GO:2000379 | positive regulation of reactive oxygen species metabolic process | CYBA, ICAM1, INSR, KLF4, TGFB1, TSPO | 1.59E-07 |
BP | GO:0043200 | response to amino acid | CFL1, COL1A1, COL6A1, CYBA, ICAM1, MMP2 | 2.18E-07 |
BP | GO:1903426 | regulation of reactive oxygen species biosynthetic process | CYBA, ICAM1, INSR, KLF4, TSPO | 8.46E-07 |
BP | GO:2000377 | regulation of reactive oxygen species metabolic process | CYBA, ICAM1, INSR, KLF4, TGFB1, TSPO | 8.80E-07 |
BP | GO:0022617 | extracellular matrix disassembly | COL1A1, COL6A1, COL8A1, LCP1, MMP2, TGFB1 | 8.92E-07 |
Module 6 | ||||
BP | GO:0002220 | innate immune response activating cell surface receptor signaling pathway | ICAM3, IL1B, NFKB1, PSMA6, PSMB8, PSMD8, TLR2 | 1.52E-07 |
BP | GO:0002223 | stimulatory C-type lectin receptor signaling pathway | ICAM3, IL1B, NFKB1, PSMA6, PSMB8, PSMD8 | 2.33E-06 |
BP | GO:0050764 | regulation of phagocytosis | CNN2, FGR, IL1B, ITGAV | 8.97E-05 |
BP | GO:0051437 | positive regulation of ubiquitin-protein ligase activity involved in regulation of mitotic cell cycle transition | ANAPC5, PSMA6, PSMB8, PSMD8 | 1.01E-04 |
BP | GO:0002479 | antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent | ITGAV, PSMA6, PSMB8, PSMD8 | 1.06E-04 |
Module 12 | ||||
BP | GO:0045740 | positive regulation of DNA replication | BMP4, CDK1, TIMP1 | 6.24E-05 |
BP | GO:0090100 | positive regulation of transmembrane receptor protein serine/threonine kinase signaling pathway | ACVR2B, BMP4, ENG | 9.44E-05 |
BP | GO:0045446 | endothelial cell differentiation | ACVR2B, BMP4, ENG | 9.74E-05 |
BP | GO:0060840 | artery development | ACVR2B, BMP4, ENG | 1.09E-04 |