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Table 2 Highly significant terms (P < 0.05 in corrected test of Benjamini-Hochberg) in BP enrichment of modules from total PPI network

From: Analysis of protein-protein interaction network based on transcriptome profiling of ovine granulosa cells identifies candidate genes in cyclic recruitment of ovarian follicles

Category GO ID GO Term Associated Genes/proteins Found Adjusted P-value
Module 1
 BP GO:0050855 regulation of B cell receptor signaling pathway LYN, PTPN6, PTPRC 3.44E-06
 BP GO:0050866 negative regulation of cell activation CCR2, CNR1, LYN, PDGFRA, PTPN6 4.23E-06
 BP GO:0002703 regulation of leukocyte mediated immunity BTK, CCR2, LYN, PTPN6, PTPRC 4.36E-06
 BP GO:0050853 B cell receptor signaling pathway BTK, LYN, PTPN6, PTPRC 7.04E-06
 BP GO:0045577 regulation of B cell differentiation BTK, PTPN6, PTPRC 1.56E-05
Module 2
 BP GO:0002431 Fc receptor mediated stimulatory signaling pathway FYN, HCK, ITPR2, ITPR3, RAC1, SYK, VAV1 6.58E-08
 BP GO:0038094 Fc-gamma receptor signaling pathway FYN, HCK, ITPR2, ITPR3, RAC1, SYK, VAV1 8.67E-08
 BP GO:0002433 immune response-regulating cell surface receptor signaling pathway involved in phagocytosis FYN, HCK, ITPR2, ITPR3, RAC1, SYK, VAV1 1.68E-07
 BP GO:0038096 Fc-gamma receptor signaling pathway involved in phagocytosis FYN, HCK, ITPR2, ITPR3, RAC1, SYK, VAV1 1.68E-07
 BP GO:0048010 vascular endothelial growth factor receptor signaling pathway FYN, ITPR2, ITPR3, RAC1, VAV1 4.86E-06
Module 4
 BP GO:2000379 positive regulation of reactive oxygen species metabolic process CYBA, ICAM1, INSR, KLF4, TGFB1, TSPO 1.59E-07
 BP GO:0043200 response to amino acid CFL1, COL1A1, COL6A1, CYBA, ICAM1, MMP2 2.18E-07
 BP GO:1903426 regulation of reactive oxygen species biosynthetic process CYBA, ICAM1, INSR, KLF4, TSPO 8.46E-07
 BP GO:2000377 regulation of reactive oxygen species metabolic process CYBA, ICAM1, INSR, KLF4, TGFB1, TSPO 8.80E-07
 BP GO:0022617 extracellular matrix disassembly COL1A1, COL6A1, COL8A1, LCP1, MMP2, TGFB1 8.92E-07
Module 6
 BP GO:0002220 innate immune response activating cell surface receptor signaling pathway ICAM3, IL1B, NFKB1, PSMA6, PSMB8, PSMD8, TLR2 1.52E-07
 BP GO:0002223 stimulatory C-type lectin receptor signaling pathway ICAM3, IL1B, NFKB1, PSMA6, PSMB8, PSMD8 2.33E-06
 BP GO:0050764 regulation of phagocytosis CNN2, FGR, IL1B, ITGAV 8.97E-05
 BP GO:0051437 positive regulation of ubiquitin-protein ligase activity involved in regulation of mitotic cell cycle transition ANAPC5, PSMA6, PSMB8, PSMD8 1.01E-04
 BP GO:0002479 antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent ITGAV, PSMA6, PSMB8, PSMD8 1.06E-04
Module 12
 BP GO:0045740 positive regulation of DNA replication BMP4, CDK1, TIMP1 6.24E-05
 BP GO:0090100 positive regulation of transmembrane receptor protein serine/threonine kinase signaling pathway ACVR2B, BMP4, ENG 9.44E-05
 BP GO:0045446 endothelial cell differentiation ACVR2B, BMP4, ENG 9.74E-05
 BP GO:0060840 artery development ACVR2B, BMP4, ENG 1.09E-04
  1. Abbreviations: BP Biological process, PPI Protein–protein interaction